Isolation, Chemical Characterization, Evaluation of Analgesic and Anti-Inflammatory Activities of Triterpenoids from the Tubers of Raphionacme vignei E. A. Bruce (Apocynaceae)

Raphionacme vignei E. A. Bruce (Apocynaceae) is a plant of the traditional African pharmacopoeia, whose parts are used in treatment various pathologies. Water-soaked R. tubers edible. The objective this study was to isolate triterpenoids from acetonic extract tubers, evaluate analgesic and anti-inflammatory activities each molecule. isolated compounds, characterized by NMR mass spectrometry, composed six triterpenoids: beta-amyrin dodecanoate 1(DDQ1), lupeol 2(DDQ2), acetate 3(DDQ3), 4(DDQ4), luepol 5(DDQ5) β-sitosterol 6(DDQ6). These molecules (DDQ2, DDQ3, DDQ4, DDQ5, DDQ6) carrageenan induced rat paw edema, with better power for DDQ2 which would be related presence function cycle DDQ4 also acetic acid contortions removal test tail on heating plate. action superior that salicylic acetyl acid, identical morphine, suggests central these two molecules. potent effect could attributed cyclopentane isoprene substitution position 19 lupane family. represent potential synthesis structural analogues and/or properties.